Acetone → Diallyl sulfone

HRID 1047508ノート

反応式

HRID 1047508 の反応式
[CH2:1](O)[CH:2]=[CH2:3].O[O:6][S:7]([O-:9])=O.[K+].[CH3:11][C:12]([CH3:14])=O>O>[CH2:1]([S:7]([CH2:14][CH:12]=[CH2:11])(=[O:9])=[O:6])[CH:2]=[CH2:3]

参加物

5

反応物 3

HCID 180AcetoneHCID 7858Allyl AlcoholHCID 23707502Potassium hydroxy sulfite

生成物 1

HCID 159797Diallyl sulfone収率 72%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A solution of allyl alcohol isomer A from Step 2: (7.11 g, 16.65 mmol) and oxone (30.75 g, 50.0 mmol) in acetone (100 mL) and water (25 mL) was stirred at RT overnight then filtered, diluted with water and AcOEt, extracted with AcOEt, dried and concentrated. The residue is purified was purified by flash-chromatography over silica gel (eluted with Hexanes/AcOEt 99:1 to 60:40) to provide 5.50 g (72%) of allylsulfone.

後処理

  1. filtrationthen filtered
  2. additiondiluted with water and AcOEt
  3. extractionextracted with AcOEt
  4. customdried
  5. concentrationconcentrated
  6. customThe residue is purified
  7. customwas purified by flash-chromatography over silica gel (eluted with Hexanes/AcOEt 99:1 to 60:40)

出典と根拠

ORDレコード
ord-59046acae8df4ad0ba5efa000f86c0cf
出典データセット
uspto-grants-2013_10
特許番号
US08569521B2

反応ノート

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