Diisopropylethylamine → 2-(3,5-Dichloro-2-hydroxy-benzenesulfonylamino)-indan-2-carboxylic acid ethyl ester

To a solution of 2-amino-indan-2-carboxylic acid ethyl ester (3.14 g, 15.3 mmol) and 3,5-dichloro-2-hydroxy-benzenesulfonyl chloride (1 g, 3.82 mmol) in anhydrous DCM (dichloromethane, 20 mL) is added DIPEA (631 μL, 3.82 mmol). The resulting solution is stirred at RT for 1 hour. The reaction solution is diluted in DCM (50 mL) and washed with water (1×5 mL) and brine (2×5 mL). The organic layer is dried over anhydrous Na2SO4 and concentrated in vacuo. The residue is purified by HPLC to give a pure product (30) as white solid (450 mg, 27%).

1. washwashed with water (1×5 mL) and brine (2×5 mL)
2. dry with materialThe organic layer is dried over anhydrous Na2SO4
3. concentrationconcentrated in vacuo
4. customThe residue is purified by HPLC

ORDレコード

ord-37032ea8bf1e4e87837147a89bf4d339

出典データセット

uspto-grants-2013_10

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US08569535B2