Methyl Laurate → 3-Dimethylaminopropyl Laurate

HRID 1048638

反応式

HRID 1048638 の反応式
[C:1]([O:14][CH3:15])(=[O:13])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH3:12].[CH3:16][N:17]([CH:19](O)[CH2:20]CC)[CH3:18]>>[C:1]([O:14][CH2:15][CH2:20][CH2:19][N:17]([CH3:18])[CH3:16])(=[O:13])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH3:12]

参加物

3

反応物 2

HCID 8139Methyl LaurateHCID 19917359Dimethylaminobutanol

生成物 1

HCID 36130803-Dimethylaminopropyl Laurate収率 67%

実験手順

To a 50-mL conical bottom plastic vial was added methyl laurate (38.5 mmol), dimethylaminobutanol (46.2 mmol, 1.2 eq), and Novozym 435 (400 mg). A syringe was inserted through the cap and two additional holes were punched for gas to exit. Nitrogen was bubbled at a rate sufficient to mix the contents. The vial was placed in a heating block set to 65° C. The reaction was monitored by GC/MS to observe the disappearance of starting material. The reaction was complete after approximately 24 hours. The reaction mixture was allowed to cool. The Novozym 435 was removed by filtration to afford the product as a pale, yellow oil (9.2 g; 67% yield) without further purification.

後処理

  1. customA syringe was inserted
  2. customthrough the cap
  3. customNitrogen was bubbled at a rate sufficient
  4. additionto mix the contents
  5. customset to 65° C
  6. temperatureto cool
  7. customThe Novozym 435 was removed by filtration
  8. customto afford the product as a pale, yellow oil (9.2 g; 67% yield)
  9. customwithout further purification

出典と根拠

ORDレコード
ord-bfabc186a21b4ca28f4e67f89d44ad30
出典データセット
uspto-grants-2016_07
特許番号
US09381147B2

関連ノート

読み込み中…