Methanol → 2-Methoxypyridine-3-carbonitrile

HRID 1048743

反応式

HRID 1048743 の反応式
[Na].[CH3:2][OH:3].Cl[C:5]1[N:12]=[CH:11][CH:10]=[CH:9][C:6]=1[C:7]#[N:8]>O>[CH3:2][O:3][C:5]1[N:12]=[CH:11][CH:10]=[CH:9][C:6]=1[C:7]#[N:8]

参加物

5

反応物 3

HCID 887MethanolHCID 810792-ChloronicotinonitrileHCID 5360545Sodium

生成物 1

HCID 2520992-Methoxypyridine-3-carbonitrile収率 81%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

4.98 g (217 mmol) of sodium is added to 80 ml of anhydrous methanol. The reaction medium is stirred at room temperature for 10 minutes and then 10 g (72.2 mmol) of 2-chloronicotinonitrile is added at 0° C. The reaction medium is stirred at 25° C. for 16 hours. The reaction is hydrolyzed by slowly adding water at 0° C. After returning to room temperature, the precipitate obtained is filtered, rinsed with water and then dried at 50° C. to yield 7.85 g (81%) of 2-methoxy-nicotinonitrile in the form of a yellow solid.

後処理

  1. stirringThe reaction medium is stirred at 25° C. for 16 hours
  2. customAfter returning to room temperature
  3. customthe precipitate obtained
  4. filtrationis filtered
  5. washrinsed with water
  6. customdried at 50° C.

出典と根拠

ORDレコード
ord-92c99cd601214552a04f44e26321ed1b
出典データセット
uspto-grants-2016_07
特許番号
US09381195B2

関連ノート

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