Hydrochloric Acid → 3-Cyclopropyl-3-(3-(((2-(2,2-dimethylpropyl)-2'-fluoro-5'-methoxybiphenyl-4-yl)amino)methyl)phenyl)propanoic acid

温度

0 °C

To a solution of ethyl 3-cyclopropyl-3-(3-(((2′-fluoro-5′-methoxy-2-neopentyl-[1,1′-biphenyl]-4-yl)amino)methyl)phenyl)propanoate (104 mg) in ethanol (2.0 mL) was added 2N aqueous sodium hydroxide solution (502 μL) at room temperature, and the mixture was stirred for 5 hr. The reaction mixture was further stirred at 50° C. for 1 hr, and the reaction mixture was cooled to 0° C. The mixture was neutralized with 1N hydrochloric acid, and extracted with ethyl acetate. The extract was dried over anhydrous sodium sulfate and the solvent was evaporated under reduced pressure to give the title compound (88 mg) as a pale-yellow gummy substance.

1. stirringThe reaction mixture was further stirred at 50° C. for 1 hr
2. extractionextracted with ethyl acetate
3. dry with materialThe extract was dried over anhydrous sodium sulfate
4. customthe solvent was evaporated under reduced pressure

ORDレコード

ord-a54d751c2d534ccc9eac677edac1e174

出典データセット

uspto-grants-2016_07

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US09382188B2