N-bromobutanimide → N-(5-bromothiazol-4-yl)acetamide
反応式
[Br:1]N1C(=O)CCC1=O.[S:9]1[CH:13]=[C:12]([NH:14][C:15](=[O:17])[CH3:16])[N:11]=[CH:10]1>CC(O)=O.C1COCC1>[Br:1][C:13]1[S:9][CH:10]=[N:11][C:12]=1[NH:14][C:15](=[O:17])[CH3:16]参加物
4
反応条件
- 温度
- 25 °C
実験手順
1-Bromopyrrolidine-2,5-dione (0.48 g, 2.67 mmol) was added to the solution of N-(thiazol-4-yl)acetamide (0.38 g, 2.67 mmol) in AcOH/THF (10 mL/10 mL). The mixture was heated to 25° C. for 2 h. The solvent was removed and the solution was adjusted to pH˜9 with 2 N NaOH solution. It was extracted with EA (3×50 mL), the combined organic phase was washed with brine, dried with Na2SO4 and concentrated to give the title compound (1.32 g, 1.45 mmol, 54.2%) as light yellow solid.
後処理
- customThe solvent was removed
- extractionIt was extracted with EA (3×50 mL)
- washthe combined organic phase was washed with brine
- dry with materialdried with Na2SO4
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-b6376ab244d74ea6a62023c32bb595e4
- 出典データセット
- uspto-grants-2016_07
- 特許番号
- US09388180B2
反応ノート
読み込み中…