Potassium Carbonate → tert-butyl 2-(3-acetyl-1H-indazol-1-yl)acetate

HRID 1052097ノート

反応式

HRID 1052097 の反応式
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]([C:10](=[O:12])[CH3:11])=[N:2]1.C([O-])([O-])=O.[K+].[K+].Br[CH2:20][C:21]([O:23][C:24]([CH3:27])([CH3:26])[CH3:25])=[O:22]>CC#N>[C:10]([C:3]1[C:4]2[C:9](=[CH:8][CH:7]=[CH:6][CH:5]=2)[N:1]([CH2:20][C:21]([O:23][C:24]([CH3:27])([CH3:26])[CH3:25])=[O:22])[N:2]=1)(=[O:12])[CH3:11]

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 79177tert-Butyl bromoacetateHCID 156841691-(1H-indazol-3-yl)ethan-1-one

生成物 1

HCID 68283733tert-butyl 2-(3-acetyl-1H-indazol-1-yl)acetate

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

反応条件

温度
90 °C

実験手順

To a solution of 1-(1H-indazol-3-yl)ethanone [4498-72-0](2 g, 12.46 mmol) in CH3CN (50 mL) was added K2CO3 (3.97 g, 28.7 mmol) and tert-butyl 2-bromoacetate (2.58 mL, 17.48 mmol). The reaction mixture was stirred at 90° C. overnight. The reaction mixture was filtered, the residue was washed with CH3CN and the filtrate was concentrated under vacuum. The material thus obtained was used directly in the next step without further purification. MS: 275 [M+H]+; tR (HPLC conditions d): 3.78 min.

後処理

  1. filtrationThe reaction mixture was filtered
  2. washthe residue was washed with CH3CN
  3. concentrationthe filtrate was concentrated under vacuum
  4. customThe material thus obtained
  5. customwas used directly in the next step without further purification
  6. custom3.78 min.

出典と根拠

ORDレコード
ord-f8492ef54865488ab95c427deb04f006
出典データセット
uspto-grants-2016_07
特許番号
US09388199B2

反応ノート

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