Trifluoroacetic acid → 2-(3-Acetyl-1H-indazol-1-yl)acetic acid

HRID 1052098ノート

反応式

HRID 1052098 の反応式
[C:1]([C:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[N:6]([CH2:13][C:14]([O:16]C(C)(C)C)=[O:15])[N:5]=1)(=[O:3])[CH3:2].C(O)(C(F)(F)F)=O>C(Cl)Cl.CO>[C:1]([C:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[N:6]([CH2:13][C:14]([OH:16])=[O:15])[N:5]=1)(=[O:3])[CH3:2]

参加物

5

反応物 2

HCID 6422Trifluoroacetic acidHCID 68283733tert-butyl 2-(3-acetyl-1H-indazol-1-yl)acetate

生成物 1

HCID 682847152-(3-Acetyl-1H-indazol-1-yl)acetic acid

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 6344Dichloromethane溶媒2 回

実験手順

To a solution of tert-butyl 2-(3-acetyl-1H-indazol-1-yl)acetate (4 g, 12.4 mmol) in CH2Cl2 (45 mL) was added TFA (15 mL, 195.0 mmol), and the reaction mixture was stirred at RT overnight. Then was then diluted with CH2Cl2 and MeOH, and volatiles were evaporated under reduced pressure to afford the title compound: MS: 219 [M+H]+; tR (HPLC conditions d): 2.78 min.

後処理

  1. customwere evaporated under reduced pressure

出典と根拠

ORDレコード
ord-c9ec591230b244e9bc7792b5d70bb29e
出典データセット
uspto-grants-2016_07
特許番号
US09388199B2

反応ノート

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