Trifluoroacetic acid → 1386457-64-2

HRID 1052105ノート

反応式

HRID 1052105 の反応式
[C:1]([C:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[N:6]([CH2:13][C:14]([O:16]C(C)(C)C)=[O:15])[N:5]=1)(=[O:3])[NH2:2].C(O)(C(F)(F)F)=O>C(Cl)Cl>[C:1]([C:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[N:6]([CH2:13][C:14]([OH:16])=[O:15])[N:5]=1)(=[O:3])[NH2:2]

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 68283122Tert-butyl 2-(3-carbamoyl-1H-indazol-1-yl)acetate

生成物 1

HCID 682833421386457-64-2

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a solution of tert-butyl 2-(3-carbamoyl-1H-indazol-1-yl)acetate (3.42 g, 12.4 mmol) in CH2Cl2 (20 mL) was added TFA (10 mL, 130 mmol) and the resulting mixture was stirred at RT for 16 h. The reaction mixture was concentrated in vacuo, the residual solid was suspended in MeOH and concentrated again in vacuo to give the title compound. MS (LC/MS): 220 [M+H]+; tR (HPLC conditions d): 1.79 min.

後処理

  1. concentrationThe reaction mixture was concentrated in vacuo
  2. concentrationconcentrated again in vacuo

出典と根拠

ORDレコード
ord-3c8f59bfd65f40498ef28df1629718b6
出典データセット
uspto-grants-2016_07
特許番号
US09388199B2

反応ノート

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