Iodine → HCID 178422150、化合物

HRID 1052110ノート

反応式

HRID 1052110 の反応式
[CH3:1][C:2]1[CH:3]=[C:4]2[CH:10]=[N:9][NH:8][C:5]2=[CH:6][N:7]=1.[I:11]I.[OH-].[K+]>CN(C=O)C.S([O-])([O-])(=O)=S.[Na+].[Na+].O>[I:11][C:10]1[C:4]2[C:5](=[CH:6][N:7]=[C:2]([CH3:1])[CH:3]=2)[NH:8][N:9]=1

参加物

7

反応物 3

HCID 807IodineHCID 14797Potassium HydroxideHCID 126684875-methyl-1H-pyrazolo[3,4-c]pyridine

生成物 1

HCID 178422150HCID 178422150、化合物

試薬・触媒・溶媒 3

HCID 962Water溶媒HCID 6228Dimethylformamide溶媒HCID 24477Sodium Thiosulfate溶媒

実験手順

To a solution of 5-methyl-1H-pyrazolo[3,4-c]pyridine [76006-06-9](1.00 g, 7.51 mmol) in DMF (15 mL) were added iodine (2.86 g, 11.3 mmol) and potassium hydroxide (1.05 g, 18.8 mmol). The reaction mixture was stirred at RT for 60 h. The mixture was diluted with 10% sodium thiosulfate and water, the resulting suspension was filtered. The solid was washed with water and dried under vacuum. MS (LC/MS): 260.0 [M+H]+; tR (HPLC conditions d): 0.28 min.

後処理

  1. filtrationthe resulting suspension was filtered
  2. washThe solid was washed with water
  3. customdried under vacuum
  4. custom0.28 min.

出典と根拠

ORDレコード
ord-93865e07fc454566b6d08724b07853c7
出典データセット
uspto-grants-2016_07
特許番号
US09388199B2

反応ノート

読み込み中…