Methanol → 3-Ethynyl-2,4-difluoro-1,5-dimethoxybenzene
反応式
[F:1][C:2]1[C:7]([O:8][CH3:9])=[CH:6][C:5]([O:10][CH3:11])=[C:4]([F:12])[C:3]=1[C:13]#[C:14][Si](C)(C)C.CO.[F-].[Cs+]>O1CCCC1>[C:13]([C:3]1[C:2]([F:1])=[C:7]([O:8][CH3:9])[CH:6]=[C:5]([O:10][CH3:11])[C:4]=1[F:12])#[CH:14]参加物
5
実験手順
To a stirred solution of [(2,6-difluoro-3,5-dimethoxyphenyl)ethynyl](trimethyl)-silane (630 mg, 2.33 mmol) in tetrahydrofuran (2 mL)/methanol (2 mL), cesium fluoride (354 mg, 2.33 mmol) was added at room temperature. After 1 hour, the reaction was quenched with saturated aq. NH4Cl, then extracted with methylene chloride. The combined organic layers were dried over MgSO4, concentrated to give the desired product (440 mg, 95%). 1H NMR (300 MHz, CDCl3): δ 6.62 (t, J=7.8 Hz, 1H), 3.89 (s, 7H) ppm.
後処理
- customthe reaction was quenched with saturated aq. NH4Cl
- extractionextracted with methylene chloride
- dry with materialThe combined organic layers were dried over MgSO4
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-7f66a31523cb4a178920a52d0ee68cd3
- 出典データセット
- uspto-grants-2016_07
- 特許番号
- US09388185B2
反応ノート
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