Sodium Hydroxide → 3-bromo-N-phenyl-1H-pyrrole-2-carboxamide

HRID 1052352ノート

反応式

HRID 1052352 の反応式
[Br:1][C:2]1[CH:6]=[CH:5][N:4](S(C2C=CC=CC=2)(=O)=O)[C:3]=1[C:16]([NH:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)=[O:17].[OH-].[Na+]>CO>[Br:1][C:2]1[CH:6]=[CH:5][NH:4][C:3]=1[C:16]([NH:18][C:19]1[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=1)=[O:17]

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 709789713-Bromo-N-phenyl-1-(phenylsulfonyl)-1H-pyrrole-2-carboxamide

生成物 1

HCID 709788613-bromo-N-phenyl-1H-pyrrole-2-carboxamide収率 64.5%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To a solution of 3-bromo-N-phenyl-1-(phenylsulfonyl)-1H-pyrrole-2-carboxamide (2.70 g of crude material) in 50 mL of methanol was added 15 mL of an aqueous 1N solution of sodium hydroxide and the mixture was stirred at room temperature during 1.5 h. At the end of this period, no starting material was detected and the reaction was elaborated in the following way: methanol was evaporated and a precipitate was formed which was filtered off and washed several times with water. The solid was dried in the vacuum oven to afford 1.14 g of the title compound that was used in the following step without any further purification.

後処理

  1. custommethanol was evaporated
  2. customa precipitate was formed which
  3. filtrationwas filtered off
  4. washwashed several times with water
  5. customThe solid was dried in the vacuum oven

出典と根拠

ORDレコード
ord-f0848885d07d4acaa3a6f4e905c17f1b
出典データセット
uspto-grants-2016_07
特許番号
US09388189B2

反応ノート

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