Trifluoroacetic acid → (S)-2-(1-Aminoethyl)-5-((3-methoxyphenyl)thio)-3-phenyl pyrrol o[2,1-f][1,2,4]triazin-4(3H)-one
反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([S:9][C:10]2[CH:11]=[CH:12][N:13]3[C:18]=2[C:17](=[O:19])[N:16]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[C:15]([C@@H:26]([NH:28]C(=O)OC(C)(C)C)[CH3:27])=[N:14]3)[CH:6]=[CH:7][CH:8]=1.FC(F)(F)C(O)=O>>[NH2:28][C@H:26]([C:15]1[N:16]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[C:17](=[O:19])[C:18]2=[C:10]([S:9][C:5]3[CH:6]=[CH:7][CH:8]=[C:3]([O:2][CH3:1])[CH:4]=3)[CH:11]=[CH:12][N:13]2[N:14]=1)[CH3:27]参加物
3
実験手順
(S)-tert-Butyl (1-(5-((3-methoxyphenyl)thio)-4-oxo-3-phenyl-3,4-dihydropyrrolo[2,1-f][1,2,4]triazin-2-yl)ethyl)carbamate (154 mg, 0.31 mmol) was treated with trifluoroacetic acid (240 μl, 3.12 mmol) according to the method of Preparation 6 to obtain 103 mg (78% yield) of the title compound as an oil. Purity 92%.