Methyl 3-bromobenzoate → m-Bromobenzohydrazide

HRID 1052603

反応式

HRID 1052603 の反応式
[Br:1][C:2]1[CH:3]=[C:4]([CH:9]=[CH:10][CH:11]=1)[C:5](OC)=[O:6].O.[NH2:13][NH2:14]>C(O)C>[Br:1][C:2]1[CH:3]=[C:4]([CH:9]=[CH:10][CH:11]=1)[C:5]([NH:13][NH2:14])=[O:6]

参加物

4

反応物 2

HCID 12070Methyl 3-bromobenzoateHCID 24654Hydrazine hydrate (1:1)

生成物 1

HCID 520941m-Bromobenzohydrazide収率 90%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
80 °C

実験手順

Methyl 3-bromobenzoate (2 g, 9.3 mmol) was dissolved in 25 ml ethanol. Hydrazine hydrate (4.5 ml, 92.9 mmol) was added and the reaction was stirred at 80° C. overnight. The reaction mixture was evaporated under reduced pressure and a white solid was formed. This solid was washed with water and diethyl ether and dried in the vacuum oven to afford 1.8 g (90% yield) of the title compound. Purity 100%.

後処理

  1. customThe reaction mixture was evaporated under reduced pressure
  2. customa white solid was formed
  3. washThis solid was washed with water and diethyl ether
  4. customdried in the vacuum oven

出典と根拠

ORDレコード
ord-c5dec2be34f44a01b83b9a791a8ab349
出典データセット
uspto-grants-2016_07
特許番号
US09388189B2

関連ノート

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