Sodium Cyanide → 2-(3-Cyanopropyl)-5-(5-methyl-2-phenyl-4-oxazolylmethoxy)benzofuran

HRID 1053

反応式

HRID 1053 の反応式
[CH3:1][C:2]1[O:6][C:5]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)=[N:4][C:3]=1[CH2:13][O:14][C:15]1[CH:16]=[CH:17][C:18]2[O:22][C:21]([CH2:23][CH2:24][CH2:25]O)=[CH:20][C:19]=2[CH:27]=1.[C-:28]#[N:29].[Na+]>>[C:28]([CH2:25][CH2:24][CH2:23][C:21]1[O:22][C:18]2[CH:17]=[CH:16][C:15]([O:14][CH2:13][C:3]3[N:4]=[C:5]([C:7]4[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=4)[O:6][C:2]=3[CH3:1])=[CH:27][C:19]=2[CH:20]=1)#[N:29]

参加物

3

反応物 2

HCID 8929Sodium CyanideHCID 196943743-[5-(5-Methyl-2-phenyl-4-oxazolylmethoxy)-2-benzofuranyl]propanol

生成物 1

HCID 196943642-(3-Cyanopropyl)-5-(5-methyl-2-phenyl-4-oxazolylmethoxy)benzofuran収率 80%

実験手順

In the same manner as in Example 13, 3-[5-(5-methyl-2-phenyl-4-oxazolylmethoxy)-2-benzofuranyl]propanol was mesylated and then reacted with sodium cyanide to yield 2-(3-cyanopropyl)-5-(5-methyl-2-phenyl-4-oxazolylmethoxy)benzofuran (yield 80%), which was then recrystallized from acetone-isopropyl ether to yield colorless prisms having a melting point of 114° to 115° C.

出典と根拠

ORDレコード
ord-667e2aee4c9a4838b14ae6bea3b0b581
出典データセット
uspto-grants-1998_03
特許番号
US05723479

関連ノート

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