Sodium Cyanide → 2-(3-Cyanopropyl)-5-(5-methyl-2-phenyl-4-oxazolylmethoxy)benzofuran
反応式
[CH3:1][C:2]1[O:6][C:5]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)=[N:4][C:3]=1[CH2:13][O:14][C:15]1[CH:16]=[CH:17][C:18]2[O:22][C:21]([CH2:23][CH2:24][CH2:25]O)=[CH:20][C:19]=2[CH:27]=1.[C-:28]#[N:29].[Na+]>>[C:28]([CH2:25][CH2:24][CH2:23][C:21]1[O:22][C:18]2[CH:17]=[CH:16][C:15]([O:14][CH2:13][C:3]3[N:4]=[C:5]([C:7]4[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=4)[O:6][C:2]=3[CH3:1])=[CH:27][C:19]=2[CH:20]=1)#[N:29]参加物
3
実験手順
In the same manner as in Example 13, 3-[5-(5-methyl-2-phenyl-4-oxazolylmethoxy)-2-benzofuranyl]propanol was mesylated and then reacted with sodium cyanide to yield 2-(3-cyanopropyl)-5-(5-methyl-2-phenyl-4-oxazolylmethoxy)benzofuran (yield 80%), which was then recrystallized from acetone-isopropyl ether to yield colorless prisms having a melting point of 114° to 115° C.
出典と根拠
- ORDレコード
- ord-667e2aee4c9a4838b14ae6bea3b0b581
- 出典データセット
- uspto-grants-1998_03
- DOI