Trifluoroacetic acid → Phenyl pyrrolidine-2-carboxylate
反応式
[N:1]1(C(OC(C)(C)C)=O)[CH2:5][CH2:4][CH2:3][CH:2]1[C:6]([O:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)=[O:7].FC(F)(F)C(O)=O>C(Cl)Cl>[NH:1]1[CH2:5][CH2:4][CH2:3][CH:2]1[C:6]([O:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)=[O:7]参加物
4
実験手順
Compound 22 (500 mg, 1.71 mmol) was dissolved in dry DCM (6 mL). Trifluoroacetic acid (0.66 mL, 8.58 mmol) was then added to the solution at 0° C. and stirred under nitrogen for 1 h. The reaction mixture was then concentrated under vacuum and used directly in the next step without further purification.
後処理
- concentrationThe reaction mixture was then concentrated under vacuum
- customused directly in the next step without further purification
出典と根拠
- ORDレコード
- ord-4be3effd17b2422eaa653e35b4a42271
- 出典データセット
- uspto-grants-2016_07
- 特許番号
- US09393306B2
反応ノート
読み込み中…