Trifluoroacetic acid → Phenyl pyrrolidine-3-carboxylate

HRID 1053522ノート

反応式

HRID 1053522 の反応式
N1CCCC1C(OC1C=CC=CC=1)=O.C(O)(C(F)(F)F)=O.[N:22]1(C(OC(C)(C)C)=O)[CH2:26][CH2:25][CH:24]([C:27]([O:29][C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)=[O:28])[CH2:23]1>>[NH:22]1[CH2:26][CH2:25][CH:24]([C:27]([O:29][C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)=[O:28])[CH2:23]1

参加物

4

反応物 3

HCID 6422Trifluoroacetic acidHCID 15598566Phenyl pyrrolidine-2-carboxylateHCID 898737321-tert-Butyl 3-phenyl pyrrolidine-1,3-dicarboxylate

生成物 1

HCID 69577543Phenyl pyrrolidine-3-carboxylate

実験手順

The compound 25 was prepared according to the method described for compound 23 employing TFA (0.66 mL, 8.58 mmol) and compound 24 (500 mg, 1.71 mmol) to give white solid compound. The compound was used without further purification after solvent removal.

後処理

  1. customto give white solid compound
  2. customThe compound was used without further purification
  3. customafter solvent removal

出典と根拠

ORDレコード
ord-0f001729c14f4ad6807ebbd1657c1e36
出典データセット
uspto-grants-2016_07
特許番号
US09393306B2

反応ノート

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