Trimethylamine → 3-{2-[2-hydroxy-1-(3-hydroxyoctyl)-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[b]naphthalen-5-yloxy]acetoxy}propionic acid

HRID 1053551

反応式

HRID 1053551 の反応式
[OH:1][CH:2]1[CH:19]([CH2:20][CH2:21][CH:22]([O:28]C2CCCCO2)[CH2:23][CH2:24][CH2:25][CH2:26][CH3:27])[CH:5]2[CH2:6][C:7]3[C:12]([CH2:13][CH:4]2[CH2:3]1)=[C:11]([O:14][CH2:15][C:16]([OH:18])=[O:17])[CH:10]=[CH:9][CH:8]=3.O[CH2:36][CH2:37][C:38]([O:40]CC1C=CC=CC=1)=[O:39].CN(C)C.C1N(P(Cl)(N2C(=O)OCC2)=O)C(=O)OC1>C(Cl)Cl.CC(OC)(C)C>[OH:1][CH:2]1[CH:19]([CH2:20][CH2:21][CH:22]([OH:28])[CH2:23][CH2:24][CH2:25][CH2:26][CH3:27])[CH:5]2[CH2:6][C:7]3[C:12]([CH2:13][CH:4]2[CH2:3]1)=[C:11]([O:14][CH2:15][C:16]([O:18][CH2:36][CH2:37][C:38]([OH:40])=[O:39])=[O:17])[CH:10]=[CH:9][CH:8]=3

参加物

7

反応物 4

HCID 1146TrimethylamineHCID 84459Propanoic acid, 3-hydroxy-, phenylmethyl esterHCID 152842Bis(2-oxo-3-oxazolidinyl)phosphinic chlorideHCID 90281645HCID 90281645、化合物

生成物 1

HCID 1214807453-{2-[2-hydroxy-1-(3-hydroxyoctyl)-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[b]naphthalen-5-yloxy]acetoxy}propionic acid

試薬・触媒・溶媒 2

HCID 6344Dichloromethane溶媒HCID 15413tert-Butyl methyl ether溶媒

実験手順

To a solution of Compound B (120 mg, 0.25 mmol), benzyl 3-hydroxypropionate (54 mg, 0.30 mmol) and trimethylamine (140 μL, 1.0 mmol) in DCM (4 mL) was added BOP—Cl (95 mg, 0.38 mmol). The reaction mixture was stirred at RT for 16 hr under nitrogen, diluted with MTBE, washed with brine, dried over sodium sulfate, and concentrated to an oil that was purified by silica gel chromatography. A solution of the THP-protected diester in ethanol (4 mL) was treated with PPTS (50 mg), stirred at 50° C. for 4 hr, and concentrated to an oil that was purified by silica gel chromatography. A solution of the THP-deprotected diester in dioxane (5 mL) was treated with wet 5% Pd/C (20 mg) and stirred for 24 hr under a balloon of hydrogen. The reaction mixture was filtered and concentrated to give crude Compound II-4. MS: m/z 485 [M+Na]+

後処理

  1. washwashed with brine
  2. dry with materialdried over sodium sulfate
  3. concentrationconcentrated to an oil that
  4. customwas purified by silica gel chromatography
  5. additionA solution of the THP-protected diester in ethanol (4 mL) was treated with PPTS (50 mg)
  6. stirringstirred at 50° C. for 4 hr
  7. concentrationconcentrated to an oil that
  8. customwas purified by silica gel chromatography
  9. additionA solution of the THP-deprotected diester in dioxane (5 mL) was treated with wet 5% Pd/C (20 mg)
  10. stirringstirred for 24 hr under a balloon of hydrogen
  11. filtrationThe reaction mixture was filtered
  12. concentrationconcentrated
  13. customto give crude Compound II-4

出典と根拠

ORDレコード
ord-99aa46029a874eeaa0d37620c04c9656
出典データセット
uspto-grants-2016_07
特許番号
US09394227B1

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