tert-Butylsulfinamide, (R)-(+)- → HCID 178465718、化合物

HRID 1053684ノート

反応式

HRID 1053684 の反応式
[CH3:1][C:2]([S@:5]([NH2:7])=[O:6])([CH3:4])[CH3:3].[Br:8][C:9]1[C:10]([CH3:18])=[C:11]([C:15](=O)[CH3:16])[CH:12]=[CH:13][CH:14]=1>C1COCC1.C(O[Ti](OCC)(OCC)OCC)C>[Br:8][C:9]1[C:10]([CH3:18])=[C:11](/[C:15](=[N:7]/[S@@:5]([C:2]([CH3:4])([CH3:3])[CH3:1])=[O:6])/[CH3:16])[CH:12]=[CH:13][CH:14]=1

参加物

5

反応物 2

HCID 10964479tert-Butylsulfinamide, (R)-(+)-HCID 204801311-(3-Bromo-2-methylphenyl)ethanone

生成物 1

HCID 178465718HCID 178465718、化合物

試薬・触媒・溶媒 2

HCID 178477244HCID 178477244、化合物触媒HCID 8028Tetrahydrofuran溶媒

反応条件

温度
75 °C

実験手順

To a stirring solution of (R)-2-methylpropane-2-sulfinamide (326 mg, 2.69 mmol) and Intermediate 12A (600 mg, 2.82 mmol) in THF (2 mL) at rt was added tetraethoxytitanium (1.06 mL, 5.12 mmol). The reaction mixture was heated at 75° C. for 16 h. The reaction mixture was cooled and used directly in the next step. LCMS=2.12 min [M+1]=318.0 (Method B).

後処理

  1. temperatureThe reaction mixture was cooled
  2. customLCMS=2.12 min [M+1]=318.0 (Method B)

出典と根拠

ORDレコード
ord-d892c17472244c0eb000762b3c79055c
出典データセット
uspto-grants-2016_07
特許番号
US09394260B2

反応ノート

読み込み中…