3-Azido-6-methoxyhexahydrofuro[3,2-b]furan → 6-Methoxyhexahydrofuro[3,2-b]furan-3-amine
反応式
[N:1]([CH:4]1[CH2:8][O:7][CH:6]2[CH:9]([O:12][CH3:13])[CH2:10][O:11][CH:5]12)=[N+]=[N-]>CO.[Pd]>[CH3:13][O:12][CH:9]1[CH:6]2[O:7][CH2:8][CH:4]([NH2:1])[CH:5]2[O:11][CH2:10]1参加物
4
実験手順
To a solution of 3-azido-6-methoxyhexahydrofuro[3,2-b]furan (0.85 g, 4.6 mmol) in MeOH (50 mL) was added Pd/C (10%, 94.5 mg). The reaction was stirred at rt overnight in 1 atm H2 atmosphere, then the mixture was filtered, and the filtrate was concentrated in vacuo. The residue was purified by silica gel column chromatography (DCM/MeOH (0.02 M NH3) (v/v)=25/1) to give the title compound as colorless oil (380 mg, 52.1%).
後処理
- filtrationthe mixture was filtered
- concentrationthe filtrate was concentrated in vacuo
- customThe residue was purified by silica gel column chromatography (DCM/MeOH (0.02 M NH3) (v/v)=25/1)
出典と根拠
- ORDレコード
- ord-5c2dd30b2dd74d3c92405a599e24b4c3
- 出典データセット
- uspto-grants-2016_07
- 特許番号
- US09394281B2
反応ノート
読み込み中…