N-bromobutanimide → 3-(Bromomethyl)-6-phenylpyridazine

HRID 1054111

反応式

HRID 1054111 の反応式
[CH3:1][C:2]1[N:3]=[N:4][C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[CH:6][CH:7]=1.C1C(=O)N([Br:21])C(=O)C1>C(Cl)(Cl)(Cl)Cl>[Br:21][CH2:1][C:2]1[N:3]=[N:4][C:5]([C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=2)=[CH:6][CH:7]=1

参加物

4

反応物 2

HCID 67184N-bromobutanimideHCID 113787443-Methyl-6-phenylpyridazine

生成物 1

HCID 667174453-(Bromomethyl)-6-phenylpyridazine

試薬・触媒・溶媒 1

HCID 5943Carbon Tetrachloride溶媒

実験手順

Synthesized using compound 65b (982 mg, 5.77 mmol), NBS (1.13 g, 6.35 mmol) and DBPO (70 mg, 0.29 mmol) in carbon tetrachloride according to Method A. Crude product was purified by flash chromatography on silica-gel using hexane/ethyl acetate (4:1) as eluent. Product was used directly in the next step without further characterization. Orange solid. Yield: 53 mg, 4%. (ESI): m/z=250.67 [M+H]+.

後処理

  1. customSynthesized
  2. customCrude product was purified by flash chromatography on silica-gel

出典と根拠

ORDレコード
ord-e12083880c59418886cef06b3e62e0f5
出典データセット
uspto-grants-2016_07
特許番号
US09394290B2

関連ノート

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