Hydrazine hydrate (1:1) → O-((4-(trifluoromethyl)phenyl)methyl)hydroxylamine
反応式
[F:1][C:2]([F:23])([F:22])[C:3]1[CH:21]=[CH:20][C:6]([CH2:7][O:8][N:9]2C(=O)C3C(=CC=CC=3)C2=O)=[CH:5][CH:4]=1.O.NN>C(O)C>[F:1][C:2]([F:22])([F:23])[C:3]1[CH:21]=[CH:20][C:6]([CH2:7][O:8][NH2:9])=[CH:5][CH:4]=1参加物
4
実験手順
To a stirring solution of 2-((4-(trifluoromethyl)benzyl)oxy)isoindoline-1,3-dione (9 g, 28.0 mmol) in ethanol (90 mL) was added hydrazine hydrate (1.543 g, 30.8 mmol) at RT. Reaction mixture was stirred for 16 h. Reaction mixture was filtered and filtrate was diluted with water and extracted with EtOAC. The organic layer was separated and distilled out to get the titled compound in 68% yield.
後処理
- customReaction mixture
- customReaction mixture
- filtrationwas filtered
- additionfiltrate was diluted with water
- extractionextracted with EtOAC
- customThe organic layer was separated
- distillationdistilled out
出典と根拠
- ORDレコード
- ord-e11eaf6e9ffe43d7b39b5fee92b1a6eb
- 出典データセット
- uspto-grants-2016_07
- 特許番号
- US09394300B2
反応ノート
読み込み中…