Ethyl 2-(trifluoromethyl)-1,3-thiazole-4-carboxylate → [2-(Trifluoromethyl)-1,3-thiazol-4-yl]methanol

HRID 1054226

反応式

HRID 1054226 の反応式
[F:1][C:2]([F:14])([F:13])[C:3]1[S:4][CH:5]=[C:6]([C:8](OCC)=[O:9])[N:7]=1.[H-].[H-].[H-].[H-].[Li+].[Al+3]>C1COCC1>[F:14][C:2]([F:1])([F:13])[C:3]1[S:4][CH:5]=[C:6]([CH2:8][OH:9])[N:7]=1

参加物

4

反応物 2

HCID 20079591Ethyl 2-(trifluoromethyl)-1,3-thiazole-4-carboxylateHCID 21226445Aluminium lithium hydride

生成物 1

HCID 20079604[2-(Trifluoromethyl)-1,3-thiazol-4-yl]methanol収率 56%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

To a stirring solution of ethyl 2-(trifluoromethyl)thiazole-4-carboxylate (1.0 g, 4.44 mmol) in THF (10 ml) was added LiAlH4 (0.169 g, 4.44 mmol) at 0-10° C. and stirred for 1 h at RT. Reaction mixture was cooled and quenched with saturated sodium sulfate solution till precipitates observed. Precipitates obtained were filtered and filtrate was evaporated to get desired product in 56% yield.

後処理

  1. customReaction mixture
  2. temperaturewas cooled
  3. customquenched with saturated sodium sulfate solution
  4. customtill precipitates
  5. customPrecipitates
  6. customobtained
  7. filtrationwere filtered
  8. customfiltrate was evaporated

出典と根拠

ORDレコード
ord-d0e96f6c79d24a58a222558e0a7838af
出典データセット
uspto-grants-2016_07
特許番号
US09394300B2

関連ノート

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