Acetyl chloride → HCID 58994978、化合物
反応式
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([C:10]2([C:16]#[N:17])[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]2)=[CH:6][CH:5]=1)([O-:3])=[O:2].[CH3:18][C:19](Cl)=[O:20].CCN(C(C)C)C(C)C>C(Cl)Cl>[C:19]([N:13]1[CH2:14][CH2:15][C:10]([C:7]2[CH:8]=[CH:9][C:4]([N+:1]([O-:3])=[O:2])=[CH:5][CH:6]=2)([C:16]#[N:17])[CH2:11][CH2:12]1)(=[O:20])[CH3:18]参加物
5
実験手順
A solution of 4-(4-nitro-phenyl)-piperidine-4-carbonitrile (as prepared in the previous step) in CH2Cl2 is treated with CH3COCl and DIEA. The mixture is washed with water, and the organic layer is dried (MgSO4) and concentrated in vacuo. The residue is purified by silica gel chromatography with the appropriate solvent to afford the title compound.
後処理
- washThe mixture is washed with water
- dry with materialthe organic layer is dried (MgSO4)
- concentrationconcentrated in vacuo
- customThe residue is purified by silica gel chromatography with the appropriate solvent
出典と根拠
- ORDレコード
- ord-514b8fb878e147c4a0f94be54cb85c1c
- 出典データセット
- uspto-grants-2016_07
- 特許番号
- US09394289B2
反応ノート
読み込み中…