Sodium borohydride → 2-(2,5-Difluorophenyl)pyrrolidine
反応式
[BH4-].[Na+].[F:3][C:4]1[CH:9]=[CH:8][C:7]([F:10])=[CH:6][C:5]=1[C:11]1[CH2:12][CH2:13][CH2:14][N:15]=1>CO.O>[F:3][C:4]1[CH:9]=[CH:8][C:7]([F:10])=[CH:6][C:5]=1[CH:11]1[CH2:12][CH2:13][CH2:14][NH:15]1参加物
4
実験手順
NaBH4 (12 g, 314.9 mmol) was added to a solution of 5-(2,5-difluorophenyl)-3,4-dihydro-2H-pyrrole (28.5 g, 157.4 mmol) in a mixture of MeOH:H2O (4:1, 250 mL) and stirring was continued at 25-35° C. for 2 h. The reaction mixture was quenched with 1N aqueous HCl solution and basified with 2N aqueous NaOH solution, extracted with DCM, dried over anhydrous sodium sulphate and concentrated under reduced pressure to afford 23 g of the title compound. MS (ESI): m/z 184 (M+H).
後処理
- customThe reaction mixture was quenched with 1N aqueous HCl solution
- extractionextracted with DCM
- dry with materialdried over anhydrous sodium sulphate
- concentrationconcentrated under reduced pressure
出典と根拠
- ORDレコード
- ord-a949c2660c104268b9ea8f14c6ca24fc
- 出典データセット
- uspto-grants-2016_07
- 特許番号
- US09394305B2
反応ノート
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