Trifluoroacetic acid → 3-(4-Bromophenoxy)azetidine

HRID 1054579ノート

反応式

HRID 1054579 の反応式
[Br:1][C:2]1[CH:19]=[CH:18][C:5]([O:6][CH:7]2[CH2:10][N:9](C(OC(C)(C)C)=O)[CH2:8]2)=[CH:4][CH:3]=1.C(O)(C(F)(F)F)=O>C(Cl)Cl>[Br:1][C:2]1[CH:19]=[CH:18][C:5]([O:6][CH:7]2[CH2:8][NH:9][CH2:10]2)=[CH:4][CH:3]=1

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 68605010Tert-butyl 3-(4-bromophenoxy)azetidine-1-carboxylate

生成物 1

HCID 249023583-(4-Bromophenoxy)azetidine収率 100.8%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a solution of tert-butyl 3-(4-bromophenoxy)azetidine-1-carboxylate (300 mg, 0.90 mmol) in CH2Cl2 (5 mL) was added TFA (5 mL). The mixture was stirred at room temperature overnight. The reaction mixture was concentrated in vacuo to give 3-(4-bromophenoxy)azetidine (207 mg, 100%) as a yellow oil.

後処理

  1. concentrationThe reaction mixture was concentrated in vacuo

出典と根拠

ORDレコード
ord-0b6157004e0647808e5ed268b9b7c8ed
出典データセット
uspto-grants-2016_07
特許番号
US09394285B2

反応ノート

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