Water → 3-Bromo-6-chloro-2-methoxypyridine
反応式
[Br:1][C:2]1[C:3](Cl)=[N:4][C:5]([Cl:8])=[CH:6][CH:7]=1.[CH3:10][O-:11].[Na+].O>C(#N)C>[Br:1][C:2]1[C:3]([O:11][CH3:10])=[N:4][C:5]([Cl:8])=[CH:6][CH:7]=1参加物
5
実験手順
To a solution of 3-bromo-2,6-dichloropyridine (3.00 g, 13.2 mmol) in acetonitrile (20 mL) was added sodium methoxide (methanol solution, 4.83 mol/L, 3.0 mL) dropwise at 0° C. The mixture was stirred at room temperature over night. To the mixture was added 30 mL of water, and the organic was evaporated. The resulting suspension was filtered, and the pad was washed with water for several times. The pad was dried under reduce pressure to give title compound (2.74 g, 93.2%) as white solid.
後処理
- customthe organic was evaporated
- filtrationThe resulting suspension was filtered
- washthe pad was washed with water for several times
- customThe pad was dried
出典と根拠
- ORDレコード
- ord-6f02dd56485b4c9cbf12cee0cded4e36
- 出典データセット
- uspto-grants-2016_07
- 特許番号
- US09394285B2
反応ノート
読み込み中…