Cyclopentylamine → N-Cyclopentylacetoacetamide

HRID 1055241ノート

反応式

HRID 1055241 の反応式
[CH:1]1([NH2:6])[CH2:5][CH2:4][CH2:3][CH2:2]1.[CH2:7]=[C:8]1[O:12][C:10](=[O:11])[CH2:9]1>O1CCCC1>[CH:1]1([NH:6][C:10](=[O:11])[CH2:9][C:8](=[O:12])[CH3:7])[CH2:5][CH2:4][CH2:3][CH2:2]1

参加物

4

反応物 2

HCID 2906CyclopentylamineHCID 12661Diketene

生成物 1

HCID 252488N-Cyclopentylacetoacetamide収率 78%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒2 回

反応条件

温度
0 °C

実験手順

A solution of 21.3 g (0.25 mol) cyclopentylamine in 50 ml tetrahydrofuran was added dropwise at −5 to 0° C. to a solution of 20 g of diketene (0.24 mol) in 200 ml tetrahydrofuran. After 1 h stirring at 0° C. no more starting material was detected by thin layer chromatography. The reaction mixture was evaporated and the residue is recrystallized from 100 ml of ethyl acetate. This gave 31.4 g (0.19 mol, 78% yield) as a white solid.

後処理

  1. customThe reaction mixture was evaporated
  2. customthe residue is recrystallized from 100 ml of ethyl acetate

出典と根拠

ORDレコード
ord-2de56b1dad9a4aa1bc2ee897bef75f2c
出典データセット
uspto-grants-2016_07
特許番号
US09394324B2

反応ノート

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