2-(4-Nitrophenyl)-1,3-dioxolane → 4-(1,3-Dioxolan-2-yl)aniline
反応式
C(=O)(O)[O-].[Na+].[N+:6]([C:9]1[CH:14]=[CH:13][C:12]([CH:15]2[O:19][CH2:18][CH2:17][O:16]2)=[CH:11][CH:10]=1)([O-])=O>CCO.[Pt](=O)=O>[O:16]1[CH2:17][CH2:18][O:19][CH:15]1[C:12]1[CH:13]=[CH:14][C:9]([NH2:6])=[CH:10][CH:11]=1参加物
5
実験手順
To a mixture of platinum dioxide (227 mg, 1.00 mmol) and sodium bicarbonate (420 mg, 5.00 mmol) under dry nitrogen was added a solution of 2-(4-nitrophenyl)-1,3-dioxolane (976 mg, 5.00 mmol) in EtOH (30.0 mL). The reaction mixture was bubbled with hydrogen for 15 min and then stirred under a hydrogen atmosphere (balloon) for 2 h. The reaction mixture was then filtered through a pad of Celite washing with MeOH. The filtrate was concentrated under reduced pressure to give the title compound (0.80 g, 96% yield).
後処理
- customThe reaction mixture was bubbled with hydrogen for 15 min
- filtrationThe reaction mixture was then filtered through a pad of Celite
- washwashing with MeOH
- concentrationThe filtrate was concentrated under reduced pressure
出典と根拠
- ORDレコード
- ord-fa1c8be2dcc84463ab18b2cbfe73e2bf
- 出典データセット
- uspto-grants-2016_07
- 特許番号
- US09394275B2
反応ノート
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