Trifluoroacetic acid → HCID 90037368、化合物
反応式
[CH3:1][C:2]1[CH:3]=[CH:4][C:5]2[NH:11][C:10](=[O:12])[C@@H:9]([NH:13]C(=O)OC(C)(C)C)[CH2:8][O:7][C:6]=2[CH:21]=1.[C:22]([OH:28])([C:24]([F:27])([F:26])[F:25])=[O:23]>ClCCl>[F:25][C:24]([F:27])([F:26])[C:22]([OH:28])=[O:23].[NH2:13][C@H:9]1[CH2:8][O:7][C:6]2[CH:21]=[C:2]([CH3:1])[CH:3]=[CH:4][C:5]=2[NH:11][C:10]1=[O:12]参加物
4
反応条件
- 温度
- 0 °C
実験手順
(S)-tert-butyl 8-methyl-4-oxo-2,3,4,5-tetrahydrobenzo[b][1,4]oxazepin-3-ylcarbamate (2.50 g, 8.55 mmol, Eq: 1.00) was dissolved in dichloromethane (DCM, 10 mL) at 0° C. and TFA (10 mL) was added. The mixture was stirred at 0° C. for 1.5 h and concentrated to give the title compound (2.69 g, 103%) which was used without purification.
後処理
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-216376a3c50e461a82a79efb2f3075ec
- 出典データセット
- uspto-grants-2016_07
- 特許番号
- US09394263B2
反応ノート
読み込み中…