2-(Difluoromethoxy)naphthalene-1-carbaldehyde → [2-(Difluoromethoxy)naphthalen-1-yl]methanol
反応式
[BH4-].[Na+].[F:3][CH:4]([F:18])[O:5][C:6]1[CH:15]=[CH:14][C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[C:7]=1[CH:16]=[O:17]>CCO.O>[F:3][CH:4]([F:18])[O:5][C:6]1[CH:15]=[CH:14][C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[C:7]=1[CH2:16][OH:17]参加物
5
実験手順
NaBH4 (255 mg, 6.73 mmol) was added to a suspension of 2-(difluoromethoxy)-1-naphthaldehyde (0.997 g, 4.49 mmol) in EtOH (29.9 mL). After 3 h the mixture was diluted with H2O, extracted with EtOAc, the combined extracts were washed with brine (200 mL), dried over Na2SO4, filtered, and the filtrate concentrated to give a residue that was purified by silica gel chromatography to provide (2-(difluoromethoxy)naphthalen-1-yl)methanol (387 mg, 39%) as an orange solid.
後処理
- extractionextracted with EtOAc
- washthe combined extracts were washed with brine (200 mL)
- dry with materialdried over Na2SO4
- filtrationfiltered
- concentrationthe filtrate concentrated
- customto give a residue that
- customwas purified by silica gel chromatography
出典と根拠
- ORDレコード
- ord-331b8d17532b4ac585ee90dc9feafdcb
- 出典データセット
- uspto-grants-2016_07
- 特許番号
- US09394263B2
反応ノート
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