3-Cyano-N-(3-{6-[1-(4-methoxybenzyl)-1H-pyrazol-4-yl]-1H-imidazo[1,2-b]pyrazol-1-yl}-4-methylphenyl)-5-(pentafluoro-lambda6-sulphanyl)benzamide → 3-Cyano-N-{4-methyl-3-[6-(1H-pyrazol-4-yl)-1H-imidazo[1,2-b]pyrazol-1-yl]phenyl}-5-(penta-fluoro-lambda6-sulphanyl)benzamide

HRID 1055747ノート

反応式

HRID 1055747 の反応式
[C:1]([C:3]1[CH:4]=[C:5]([CH:38]=[C:39]([S:41]([F:46])([F:45])([F:44])([F:43])[F:42])[CH:40]=1)[C:6]([NH:8][C:9]1[CH:14]=[CH:13][C:12]([CH3:15])=[C:11]([N:16]2[C:23]3[N:19]([N:20]=[C:21]([C:24]4[CH:25]=[N:26][N:27](CC5C=CC(OC)=CC=5)[CH:28]=4)[CH:22]=3)[CH:18]=[CH:17]2)[CH:10]=1)=[O:7])#[N:2]>FC(F)(F)C(O)=O>[C:1]([C:3]1[CH:4]=[C:5]([CH:38]=[C:39]([S:41]([F:46])([F:43])([F:42])([F:44])[F:45])[CH:40]=1)[C:6]([NH:8][C:9]1[CH:14]=[CH:13][C:12]([CH3:15])=[C:11]([N:16]2[C:23]3[N:19]([N:20]=[C:21]([C:24]4[CH:25]=[N:26][NH:27][CH:28]=4)[CH:22]=3)[CH:18]=[CH:17]2)[CH:10]=1)=[O:7])#[N:2]

参加物

3

反応物 1

HCID 896995663-Cyano-N-(3-{6-[1-(4-methoxybenzyl)-1H-pyrazol-4-yl]-1H-imidazo[1,2-b]pyrazol-1-yl}-4-methylphenyl)-5-(pentafluoro-lambda6-sulphanyl)benzamide

生成物 1

HCID 1366302433-Cyano-N-{4-methyl-3-[6-(1H-pyrazol-4-yl)-1H-imidazo[1,2-b]pyrazol-1-yl]phenyl}-5-(penta-fluoro-lambda6-sulphanyl)benzamide

試薬・触媒・溶媒 1

HCID 6422Trifluoroacetic acid溶媒

実験手順

80 mg (0.10 mmol) of the compound of Example 75A were stirred in 0.8 ml of trifluoroacetic acid at 90° C. for 60 min. The reaction was then concentrated under reduced pressure and the residue was purified by preparative HPLC (Method 34). This gave 49 mg (90% of theory) of the title compound.

後処理

  1. concentrationThe reaction was then concentrated under reduced pressure
  2. customthe residue was purified by preparative HPLC (Method 34)

出典と根拠

ORDレコード
ord-dc1fc08e4e124644b77ab7ccd193fb38
出典データセット
uspto-grants-2016_07
特許番号
US09394309B2

反応ノート

読み込み中…