Pyridine → (5-{1-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2-hydroxy-ethylcarbamoyl}-pentyl)-carbamic acid 17-(1,5-dimethyl-hexyl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl ester

HRID 1055788

反応式

HRID 1055788 の反応式
[CH3:1][CH:2]([CH:9]1[C:25]2([CH3:26])[CH:12]([CH:13]3[CH:22]([CH2:23][CH2:24]2)[C:21]2([CH3:27])[C:16]([CH2:17][CH:18]([O:28][C:29](=[O:44])[NH:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][C:36](=[O:43])[NH:37][CH:38]([CH2:41][OH:42])[CH2:39][OH:40])[CH2:19][CH2:20]2)=[CH:15][CH2:14]3)[CH2:11][CH2:10]1)[CH2:3][CH2:4][CH2:5][CH:6]([CH3:8])[CH3:7].CN([C:48]1[CH:53]=[CH:52][CH:51]=[CH:50]N=1)C.[C:54](Cl)(C1C=CC=CC=1)([C:63]1[CH:70]=[CH:69][C:66]([O:67][CH3:68])=[CH:65][CH:64]=1)[C:55]1[CH:62]=[CH:61][C:58]([O:59][CH3:60])=[CH:57][CH:56]=1.N1C=CC=C[CH:79]=1>>[CH3:1][CH:2]([CH:9]1[C:25]2([CH3:26])[CH:12]([CH:13]3[CH:22]([CH2:23][CH2:24]2)[C:21]2([CH3:27])[C:16]([CH2:17][CH:18]([O:28][C:29](=[O:44])[NH:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][C:36](=[O:43])[NH:37][CH:38]([CH:39]([C:50]4[CH:79]=[CH:48][CH:53]=[CH:52][CH:51]=4)[O:40][CH:54]([C:55]4[CH:62]=[CH:61][C:58]([O:59][CH3:60])=[CH:57][CH:56]=4)[C:63]4[CH:64]=[CH:65][C:66]([O:67][CH3:68])=[CH:69][CH:70]=4)[CH2:41][OH:42])[CH2:19][CH2:20]2)=[CH:15][CH2:14]3)[CH2:11][CH2:10]1)[CH2:3][CH2:4][CH2:5][CH:6]([CH3:7])[CH3:8]

参加物

5

反応物 4

HCID 1049Pyridine2 回HCID 218852-DimethylaminopyridineHCID 968311,1'-(Chlorophenylmethylene)bis(4-methoxybenzene)HCID 68636631[5-(2-Hydroxy-1-hydroxymethyl-ethylcarbamoyl)-pentyl]-carbamic acid 17-(1,5-dimethyl-hexyl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl ester

生成物 1

HCID 131728218(5-{1-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2-hydroxy-ethylcarbamoyl}-pentyl)-carbamic acid 17-(1,5-dimethyl-hexyl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl ester

実験手順

Diol 52 (5.6 g, 9.1 mmol) was co-evaporated with anhydrous pyridine three times and then dissolved in pyridine (10 mL). To this solution dimethylamino pyridine (0.110 g, 0.91 mmol) and DMT-Cl (3.23 g, 9.53 mmol, 1.05 equiv.) were added at room temperature. The reaction mixture was stirred at room temperature for 16 h. Due to the presence of two primary hydroxyl groups, the reaction never went to completion. The solution was dried under reduced pressure and co-evaporated with toluene to remove residual pyridine. To the residue was suspended in ethyl acetate (200 mL) and washed with saturated bicarbonate solution, brine and water. The organic layer was dried over anhydrous sodium sulfate, filtered and evaporated. The crude product was obtained after removal of the solvent. Upon purification over silica gel using 2% MeOH/DCM compound 53 (0.680 g, 10%) was obtained as white foamy solid.

後処理

  1. customDue to the presence of two primary hydroxyl groups, the reaction
  2. dry with materialThe solution was dried under reduced pressure and co-evaporated with toluene
  3. customto remove residual pyridine
  4. washwashed with saturated bicarbonate solution, brine and water
  5. dry with materialThe organic layer was dried over anhydrous sodium sulfate
  6. filtrationfiltered
  7. customevaporated

出典と根拠

ORDレコード
ord-5f13395fca2b41e39d9b2cfd5908e822
出典データセット
uspto-grants-2016_07
特許番号
US09394540B2

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