Diisopropylethylamine → HCID 178522456、化合物

HRID 1055994

反応式

HRID 1055994 の反応式
[O:1]([C:8]1[CH:17]=[CH:16][C:15]2[C:10](=[C:11]([C:18]([OH:20])=O)[CH:12]=[CH:13][CH:14]=2)[N:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH2:21][C:22]1[C:23]([OH:29])=[N:24][CH:25]=[CH:26][C:27]=1[OH:28].CN(C(ON1N=NC2C=CC=NC1=2)=[N+](C)C)C.F[P-](F)(F)(F)(F)F.CCN(C(C)C)C(C)C>CN(C=O)C>[OH:29][C:23]1[C:22]([NH:21][C:18]([C:11]2[CH:12]=[CH:13][CH:14]=[C:15]3[C:10]=2[N:9]=[C:8]([O:1][C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=2)[CH:17]=[CH:16]3)=[O:20])=[C:27]([OH:28])[CH:26]=[CH:25][N:24]=1

参加物

6

反応物 4

HCID 81531DiisopropylethylamineHCID 9886157Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)HCID 897820882-Phenoxyquinoline-8-carboxylic acidHCID 1785080833-amino-2-hydroxy-1H-pyridin-4-one

生成物 1

HCID 178522456HCID 178522456、化合物

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

A mixture of 2-phenoxyquinoline-8-carboxylic acid (178c 217 mg, 0.818 mmol), 3-aminopyridine-2,4-diol (155 mg, 1.227 mmol), HATU (622 mg, 1.636 mmol), and DIPEA (438 μl, 2.454 mmol) in DMF (1636 μl) was stirred at RT for 1 h. Purification by silica gel (100% DCM to 5% MeOH/DCM) provided N-(2,4-dihydroxypyridin-3-yl)-2-phenoxyquinoline-8-carboxamide (179c) as a yellow solid. MS (ESI, pos. ion) m/z: 374.2 (M+1).

後処理

  1. customPurification by silica gel (100% DCM to 5% MeOH/DCM)

出典と根拠

ORDレコード
ord-27e138d7787144b88819949eb8b75c10
出典データセット
uspto-grants-2016_07
特許番号
US09394297B2

関連ノート

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