Phosphorus oxybromide → 2,8-Dibromoquinoline

HRID 1056053

反応式

HRID 1056053 の反応式
P(Br)(Br)([Br:3])=O.[Br:6][C:7]1[CH:8]=[CH:9][CH:10]=[C:11]2[C:16]=1[NH:15][C:14](=O)[CH:13]=[CH:12]2>>[Br:3][C:14]1[CH:13]=[CH:12][C:11]2[C:16](=[C:7]([Br:6])[CH:8]=[CH:9][CH:10]=2)[N:15]=1

参加物

3

反応物 2

HCID 24613Phosphorus oxybromideHCID 109330948-Bromo-1,2-dihydroquinolin-2-one

生成物 1

HCID 459259512,8-Dibromoquinoline収率 64%

反応条件

温度
125 °C

実験手順

A mixture of phosphorus oxybromide (1.59 g, 5.55 mmol) and 8-bromo-2(1H)-quinolinone (0.250 g, 1.11 mmol) was heated at 125° C. for 2 h before being poured onto ice. The resulting precipitate was filtered and crystallized from MeOH to give 2,8-dibromo-quinoline (0.2 g, 64%) as colorless prisms. MS (ESI, pos. ion) m/z: 287.8 (M+1).

後処理

  1. additionbefore being poured onto ice
  2. filtrationThe resulting precipitate was filtered
  3. customcrystallized from MeOH

出典と根拠

ORDレコード
ord-6e9d9aa5f6fb4a3eb57a0be875163924
出典データセット
uspto-grants-2016_07
特許番号
US09394297B2

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