Pyruvic Acid → HCID 178432270、化合物
反応式
[NH2:1][C:2]1[C:3]([Cl:9])=[N:4][CH:5]=[CH:6][C:7]=1[NH2:8].[C:10](O)(=[O:14])[C:11]([CH3:13])=O>CO>[Cl:9][C:3]1[C:2]2=[N:1][C:10]([OH:14])=[C:11]([CH3:13])[N:8]=[C:7]2[CH:6]=[CH:5][N:4]=1参加物
4
反応条件
- 温度
- 50 °C
実験手順
A mixture of 3,4-diamino-2-chloropyridine (2.1 g, 14.63 mmol) (Sigma Aldich) and pyruvic acid (1.22 mL, 17.55 mmol) (Acros, New Jersey) in MeOH (40 mL) in a sealed glass tube was heated at 50° C. for 2 h. The mixture was cooled to RT and the solvent was removed in vacuo. The residue was triturated with ether and the suspension was filtered to give 1.88 g of crude product. MS (ESI, pos. ion) m/z: 196.1 (M+1).
後処理
- temperatureThe mixture was cooled to RT
- customthe solvent was removed in vacuo
- customThe residue was triturated with ether
- filtrationthe suspension was filtered
出典と根拠
- ORDレコード
- ord-5c3cc1e123fc447d8c33780bcb59abdc
- 出典データセット
- uspto-grants-2016_07
- 特許番号
- US09394297B2
反応ノート
読み込み中…