Pyruvic Acid → HCID 178432270、化合物

HRID 1056243

反応式

HRID 1056243 の反応式
[NH2:1][C:2]1[C:3]([Cl:9])=[N:4][CH:5]=[CH:6][C:7]=1[NH2:8].[C:10](O)(=[O:14])[C:11]([CH3:13])=O>CO>[Cl:9][C:3]1[C:2]2=[N:1][C:10]([OH:14])=[C:11]([CH3:13])[N:8]=[C:7]2[CH:6]=[CH:5][N:4]=1

参加物

4

反応物 2

HCID 1060Pyruvic AcidHCID 2857362-Chloropyridine-3,4-diamine

生成物 1

HCID 178432270HCID 178432270、化合物収率 65.7%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

反応条件

温度
50 °C

実験手順

A mixture of 3,4-diamino-2-chloropyridine (2.1 g, 14.63 mmol) (Sigma Aldich) and pyruvic acid (1.22 mL, 17.55 mmol) (Acros, New Jersey) in MeOH (40 mL) in a sealed glass tube was heated at 50° C. for 2 h. The mixture was cooled to RT and the solvent was removed in vacuo. The residue was triturated with ether and the suspension was filtered to give 1.88 g of crude product. MS (ESI, pos. ion) m/z: 196.1 (M+1).

後処理

  1. temperatureThe mixture was cooled to RT
  2. customthe solvent was removed in vacuo
  3. customThe residue was triturated with ether
  4. filtrationthe suspension was filtered

出典と根拠

ORDレコード
ord-5c3cc1e123fc447d8c33780bcb59abdc
出典データセット
uspto-grants-2016_07
特許番号
US09394297B2

関連ノート

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