反応式
C([O:8][C:9]1[C:10]([CH3:34])=[CH:11][C:12]([F:33])=[C:13]([CH:32]=1)[O:14][C:15]1[C:24]2[C:19](=[CH:20][C:21]([O:27][CH2:28][CH2:29][O:30][CH3:31])=[C:22]([O:25][CH3:26])[CH:23]=2)[N:18]=[N:17][CH:16]=1)C1C=CC=CC=1>CO.CN(C=O)C.[Pd]>[F:33][C:12]1[CH:11]=[C:10]([CH3:34])[C:9]([OH:8])=[CH:32][C:13]=1[O:14][C:15]1[C:24]2[C:19](=[CH:20][C:21]([O:27][CH2:28][CH2:29][O:30][CH3:31])=[C:22]([O:25][CH3:26])[CH:23]=2)[N:18]=[N:17][CH:16]=1参加物
5
実験手順
A solution of 4-(5-benzyloxy-2-fluoro-4-methylphenoxy)-6-methoxy-7-(2-methoxyethoxy)cinnoline (242 mg, 0.5 mmol) in a mixture of methanol (9 ml) and DMF (10.5 ml) containing 10% palladium-on-charcoal catalyst (100 mg) was stirred under hydrogen at 5 atmospheres pressure for 9 hours. The catalyst was removed by filtration and the solvent was evaporated. The residue was washed with methanol and ether and dried under vacuum to give 4-(2-fluoro-5-hydroxy-4-methylphenoxy)-6-methoxy-7-(2-methoxyethoxy)cinnoline as a white solid (87 mg, 44%).
後処理
- customThe catalyst was removed by filtration
- customthe solvent was evaporated
- washThe residue was washed with methanol and ether
- customdried under vacuum
出典と根拠
- ORDレコード
- ord-0bab9b29563c40089e900d37d968dc17
- 出典データセット
- uspto-grants-2003_02
- 特許番号
- US06514971B1
関連ノート
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