Guaiacol → Ethyl (2-methoxyphenoxy)acetate

HRID 1057938ノート

反応式

HRID 1057938 の反応式
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[OH:9].C(=O)([O-])[O-].[K+].[K+].Br[CH2:17][C:18]([O:20][CH2:21][CH3:22])=[O:19]>CC(C)=O>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[O:9][CH2:17][C:18]([O:20][CH2:21][CH3:22])=[O:19]

参加物

5

反応物 3

HCID 460GuaiacolHCID 7748Ethyl bromoacetateHCID 11430Potassium Carbonate

生成物 1

HCID 83114Ethyl (2-methoxyphenoxy)acetate

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

A mixture of 2-methoxyphenol (11.3 g), potassium carbonate (25 g), ethyl bromoacetate (12 ml), and acetone (113 ml) was heated under reflux for 4 hours. After cooling to the room temperature, the mixture was filtered and the solvent was distilled off under reduced pressure from the filtrate. The residue was purified by silica gel column chromatography (hexane/ethyl acetate=4/1) to give Compound IIbd-a (17 g, 91%) as a pale-yellow oily substance.

後処理

  1. temperaturewas heated
  2. temperatureunder reflux for 4 hours
  3. filtrationthe mixture was filtered
  4. distillationthe solvent was distilled off under reduced pressure from the filtrate
  5. customThe residue was purified by silica gel column chromatography (hexane/ethyl acetate=4/1)
  6. customto give Compound IIbd-a (17 g, 91%) as a pale-yellow oily substance

出典と根拠

ORDレコード
ord-03b4c84422e74e7cae602fc469941ece
出典データセット
uspto-grants-2003_02
特許番号
US06514996B2

反応ノート

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