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Acetone → Rosiglitazone Maleate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Acetone | HCID 180 | — |
| 反応物 | Rosiglitazone | HCID 77999 | — |
| 反応物 | Maleic Acid | HCID 444266 | — |
| 生成物 | Rosiglitazone Maleate | HCID 5281055 | — |
| 生成物 | maleate salt 5-[4-[2-(N-methyl-N-(2-pyridyl)amino)ethoxy]benzyl]thiazolidine-2,4-dione maleate | HCID 131723756 | — |
反応手順
In the final step of salt formation, rosiglitazone (V) and maleic acid were refluxed in acetone at 50° to 55° C. to obtain the maleate salt 5-[4-[2-(N-methyl-N-(2-pyridyl)amino)ethoxy]benzyl]thiazolidine-2,4-dione maleate (1), namely rosiglitazone maleate in high yield of 90 to 95% with high grade purity and low moisture content to be effectively dry and free flowing so that it can easily be converted into a pharmaceutical composition.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06515132B2 |
| 出典データセット | uspto-grants-2003_02 |
| ORD ID | ord-4dc8adbb61bd4210a1a090bb75ed5a70 |
| 出典メモ | uspto-grants-2003_02 |