HRID1058089

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID180

Acetone

C3H6O

结构：CN(CCOc1ccc(CC2SC(=O)NC2=O)cc1)c1ccccn1

HCID77999

Rosiglitazone

C18H19N3O3S

$结构：O=C(O)/C=C\C(=O)O$

HCID444266

Maleic acid

C4H4O4

PRODUCTS

生成物

$结构：CN(CCOc1ccc(CC2SC(=O)NC2=O)cc1)c1ccccn1.O=C(O)/C=C\C(=O)O$

HCID5281055

Rosiglitazone maleate

C22H23N3O7S

$结构：CN(CCOc1ccc(CC2SC(=O)NC2=O)cc1)c1ccccn1.O=C(O)/C=C\C(=O)O.O=C(O)/C=C\C(=O)O$

HCID131723756

未命名化合物

PROCEDURE

实验过程

In the final step of salt formation, rosiglitazone (V) and maleic acid were refluxed in acetone at 50° to 55° C. to obtain the maleate salt 5-[4-[2-(N-methyl-N-(2-pyridyl)amino)ethoxy]benzyl]thiazolidine-2,4-dione maleate (1), namely rosiglitazone maleate in high yield of 90 to 95% with high grade purity and low moisture content to be effectively dry and free flowing so that it can easily be converted into a pharmaceutical composition.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-4dc8adbb61bd4210a1a090bb75ed5a70
来源数据集: uspto-grants-2003_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06515132B2
来源说明: uspto-grants-2003_02

反应 SMILES

[CH3:1][N:2]([CH2:9][CH2:10][O:11][C:12]1[CH:25]=[CH:24][C:15]([CH2:16][CH:17]2[S:21][C:20](=[O:22])[NH:19][C:18]2=[O:23])=[CH:14][CH:13]=1)[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][N:4]=1.[C:26]([OH:33])(=[O:32])/[CH:27]=[CH:28]\[C:29]([OH:31])=[O:30].CC(C)=O>>[C:26]([OH:33])(=[O:32])/[CH:27]=[CH:28]\[C:29]([OH:31])=[O:30].[CH3:1][N:2]([CH2:9][CH2:10][O:11][C:12]1[CH:25]=[CH:24][C:15]([CH2:16][CH:17]2[S:21][C:20](=[O:22])[NH:19][C:18]2=[O:23])=[CH:14][CH:13]=1)[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][N:4]=1.[C:26]([OH:33])(=[O:32])/[CH:27]=[CH:28]\[C:29]([OH:31])=[O:30].[CH3:1][N:2]([C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][N:4]=1)[CH2:9][CH2:10][O:11][C:12]1[CH:25]=[CH:24][C:15]([CH2:16][CH:17]2[S:21][C:20](=[O:22])[NH:19][C:18]2=[O:23])=[CH:14][CH:13]=1.[CH:27](/[C:26]([OH:33])=[O:32])=[CH:28]/[C:29]([OH:31])=[O:30]