3,5,5-Trimethylhexanoic acid → n-(3,5,5-Trimethylhexanoyl)-2-butyloctylamine

HRID 1058198ノート

反応式

HRID 1058198 の反応式
[CH3:1][CH:2]([CH2:7][C:8]([CH3:11])([CH3:10])[CH3:9])[CH2:3][C:4]([OH:6])=O.[CH2:12]([CH:16]([CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH3:24])[CH2:17][NH2:18])[CH2:13][CH2:14][CH3:15].CC(N)=NCC1C=CC=C(CN)C=1.Cl.Cl>CCCCCCC>[CH3:1][CH:2]([CH2:7][C:8]([CH3:11])([CH3:10])[CH3:9])[CH2:3][C:4]([NH:18][CH2:17][CH:16]([CH2:12][CH2:13][CH2:14][CH3:15])[CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH3:24])=[O:6]

参加物

5

反応物 3

HCID 909603,5,5-Trimethylhexanoic acidHCID 27335151400w DihydrochlorideHCID 186732842-Butyl-n-octan-1-amine

生成物 1

HCID 18673287n-(3,5,5-Trimethylhexanoyl)-2-butyloctylamine収率 77%

試薬・触媒・溶媒 1

HCID 8900Heptane溶媒

実験手順

29.2 g of 3,5,5-trimethylhexanoic acid and 34.2 g of 2-butyloctylamine were mixed together in an open Pyrex container and placed in a microwave oven (Menumaster™ 3100i; frequency 2450, power at a setting of 30%: 1400 W). After 6 irradiations of about 5 minutes (for each irradiation), the reaction mixture was dissolved in heptane and then purified on silica. 46 g (77%) of the desired amide were obtained.

後処理

  1. customplaced in a microwave oven
  2. customAfter 6 irradiations of about 5 minutes (for each irradiation), the reaction mixture
  3. custompurified on silica

出典と根拠

ORDレコード
ord-599de75bac154b43a07d5dd67362d68d
出典データセット
uspto-grants-2003_02
特許番号
US06515178B2

反応ノート

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