Hydrochloric Acid → 2-(4-Chlorophenyl)nicotinic acid

HRID 1058319ノート

反応式

HRID 1058319 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:17]=[CH:16][CH:15]=[CH:14][C:9]=2[C:10]([O:12]C)=[O:11])=[CH:4][CH:3]=1.[OH-].[Na+].Cl>CO>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[N:17]=[CH:16][CH:15]=[CH:14][C:9]=2[C:10]([OH:12])=[O:11])=[CH:6][CH:7]=1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 15318002Methyl 2-(4-chlorophenyl)nicotinate

生成物 1

HCID 136013732-(4-Chlorophenyl)nicotinic acid

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To a solution containing methyl 2-(4-chlorophenyl)nicotinate from the previous step (6.0 g, 24.2 mmol) in methyl alcohol (30 mL) was added 1N sodium hydroxide (29 mL). The mixture was stirred at room temperature overnight then neutralized with 1N hydrochloric acid (29 mL), evaporated in vacuo and dried overnight to yield the solid 2-(4-chlorophenyl)nicotinic acid (7.3 g, Theo. Yield=5.65 g, balance is NaCl; HPLC RT=2.17 min; LC-MS m/z=234).

後処理

  1. customevaporated in vacuo
  2. customdried overnight

出典と根拠

ORDレコード
ord-e522d7fb69e74804a905a8e2baac2be9
出典データセット
uspto-grants-2003_02
特許番号
US06515011B2

反応ノート

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