HCID 10909824、化合物 → 4-Isopropylthiazole-5-carbaldehyde
反応式
[CH3:1][CH:2]([C:4]1[N:5]=[CH:6][S:7][C:8]=1[CH2:9][OH:10])[CH3:3]>C(#N)C.[O-2].[O-2].[Mn+4]>[CH3:1][CH:2]([C:4]1[N:5]=[CH:6][S:7][C:8]=1[CH:9]=[O:10])[CH3:3]参加物
4
実験手順
Portions of manganese dioxide (330 mg, 3.8 mmol) were added to a stirred solution of 4-(1-methylethyl)thiazole-5-methanol (Example 26; 330 mg, 2.1 mmol) in acetonitrile (10 mL) at hourly intervals for 4 h. One h after the last addition, the reaction mixture was filtered through Celite® and evaporated to dryness to give 4-(1-methylethyl)thiazole-5-carboxaldehyde (360 mg, 110% of the theoretical amount). Examination of the product by NMR indicated the presence of acetonitrile. This material was used with further purification in subsequent transformations.
後処理
- additionOne h after the last addition
- filtrationthe reaction mixture was filtered through Celite®
- customevaporated to dryness
出典と根拠
- ORDレコード
- ord-d3709346b06c45b5bbb5a5ff42bd23ad
- 出典データセット
- uspto-grants-2003_02
- 特許番号
- US06515124B2
反応ノート
読み込み中…