2-(2-Bromoethoxy)tetrahydro-2H-pyran → 1-(2-Hydroxyethyl)-4-(4-methyl-5-isoquinolyl)aminopiperidine hydrochloride

HRID 10584

反応式

HRID 10584 の反応式
Br[CH2:2][CH2:3][O:4]C1CCCCO1.[ClH:11].[CH3:12][C:13]1[C:22]2[C:17](=[CH:18][CH:19]=[CH:20][C:21]=2[NH:23][CH:24]2[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]2)[CH:16]=[N:15][CH:14]=1>>[ClH:11].[OH:4][CH2:3][CH2:2][N:27]1[CH2:28][CH2:29][CH:24]([NH:23][C:21]2[CH:20]=[CH:19][CH:18]=[C:17]3[C:22]=2[C:13]([CH3:12])=[CH:14][N:15]=[CH:16]3)[CH2:25][CH2:26]1

参加物

3

反応物 2

HCID 866212-(2-Bromoethoxy)tetrahydro-2H-pyranHCID 219798104-Methyl-N-(piperidin-4-YL)isoquinolin-5-amine hydrochloride

生成物 1

HCID 219799831-(2-Hydroxyethyl)-4-(4-methyl-5-isoquinolyl)aminopiperidine hydrochloride

実験手順

According to the method of Example 144, an alkylation reaction with 2-(2-bromoethoxy)tetrahydro-2H-pyran and a deprotection reaction were performed by using the compound of Example 106 to obtain the title compound.

後処理

  1. customa deprotection reaction

出典と根拠

ORDレコード
ord-d00bddfa7b8a4ef6b23783ff72234805
出典データセット
uspto-grants-2006_08
特許番号
US07094789B2

関連ノート

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