Dichloromethane → 3-(4-Methylpiperazin-1-yl)benzoic acid
反応式
C([O:5][C:6](=[O:20])[C:7]1[CH:12]=[CH:11][CH:10]=[C:9]([N:13]2[CH2:18][CH2:17][N:16]([CH3:19])[CH2:15][CH2:14]2)[CH:8]=1)(C)(C)C.C(Cl)Cl>C(O)(C(F)(F)F)=O.C1(C)C=CC=CC=1>[CH3:19][N:16]1[CH2:15][CH2:14][N:13]([C:9]2[CH:8]=[C:7]([CH:12]=[CH:11][CH:10]=2)[C:6]([OH:20])=[O:5])[CH2:18][CH2:17]1参加物
5
実験手順
3-(4-Methylpiperazinyl)-benzoic acid tert-butyl ester (4.1 g, 14.9 mmol) was dissolved in TFA: CH2Cl2 (70 ml, 1:1) and the reaction was stirred for 2 h at RT. The reaction mixture was diluted with toluene (100 ml), then was concentrated in vacuo and was used in the next reaction without further purification: MS (ES+) 221.3 (M+H+).
後処理
- concentrationwas concentrated in vacuo
- customwas used in the next reaction without further purification
出典と根拠
- ORDレコード
- ord-d3109afe8a8a4b86b0ce03a452ab6b4a
- 出典データセット
- uspto-grants-2003_02
- 特許番号
- US06518267B1
反応ノート
読み込み中…