Sodium Iodide → Cyclopentane, (2-iodoethoxy)-

HRID 1058753ノート

反応式

HRID 1058753 の反応式
BrC1C=CC(S(O[CH2:12][CH2:13][O:14][CH:15]2[CH2:19][CH2:18][CH2:17][CH2:16]2)(=O)=O)=CC=1.[I-:20].[Na+]>CC(C)=O>[I:20][CH2:12][CH2:13][O:14][CH:15]1[CH2:19][CH2:18][CH2:17][CH2:16]1

参加物

4

反応物 2

HCID 5238Sodium IodideHCID 18669129HCID 18669129、化合物

生成物 1

HCID 18669143Cyclopentane, (2-iodoethoxy)-収率 37%

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

To a solution of 2-(cyclopentyloxy)ethyl 4-bromobenzenesulfonate (Preparation 16, 60 mg, 0.17 mmol) in acetone (5 mL) at room temperature was added sodium iodide (200 mg, 1.3 mmol). The mixture was,heated at 35° C. for 16 hours and then cooled. The residual precipitate was removed by filtration and the filtrate was concentrated in vacuo. The residue was partitioned between diethyl ether (10 mL) and water (10 mL). The two layers were separated and the organic layer was dried over sodium sulfate, filtered, and concentrated in vacuo to give the title compound (15 mg, 37%) as a brown oil.

後処理

  1. temperaturecooled
  2. customThe residual precipitate was removed by filtration
  3. concentrationthe filtrate was concentrated in vacuo
  4. customThe residue was partitioned between diethyl ether (10 mL) and water (10 mL)
  5. customThe two layers were separated
  6. dry with materialthe organic layer was dried over sodium sulfate
  7. filtrationfiltered
  8. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-8b9601cdb4ce4404aeaccbdbe6e906e4
出典データセット
uspto-grants-2003_02
特許番号
US06518282B1

反応ノート

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