Hydrochloric Acid → 2-Benzyl-3-[(1-{[(benzyloxy)carbonyl]amino}-2-phenylethyl)(hydroxy)phosphoryl]propanoic acid

HRID 1058760ノート

反応式

HRID 1058760 の反応式
[OH:1][P:2]([CH:17]([NH:25][C:26]([O:28][CH2:29][C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1)=[O:27])[CH2:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)([CH2:4][CH:5]([CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)[C:6]([O:8]C)=[O:7])=[O:3].[OH-].[Na+].Cl>CO>[OH:3][P:2]([CH:17]([NH:25][C:26]([O:28][CH2:29][C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1)=[O:27])[CH2:18][C:19]1[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=1)([CH2:4][CH:5]([CH2:10][C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1)[C:6]([OH:8])=[O:7])=[O:1]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 18668709Methyl 3-[hydroxy[2-phenyl-1-[[(phenylmethoxy)carbonyl)amino]ethyl]phosphinyl]-2-(phenylmethyl)propanoate

生成物 1

HCID 186687012-Benzyl-3-[(1-{[(benzyloxy)carbonyl]amino}-2-phenylethyl)(hydroxy)phosphoryl]propanoic acid収率 100%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To a solution of 1 g (2.02 mmol) of methyl 3-[hydroxy[2-phenyl-1-[[(phenylmethoxy)carbonyl)amino]ethyl]phosphinyl]-2-(phenylmethyl)propanoate in 20 ml of methanol are added 20 ml of 1N sodium hydroxide. After stirring for 10 hours, the medium is acidified with 2N hydrochloric acid, the methanol is then evaporated off and the residue is extracted three times with ethyl acetate. The combined organic phases are washed with water, dried over sodium sulphate and evaporated. 0.97 g of product is recovered (yield=100%).

後処理

  1. customthe methanol is then evaporated off
  2. extractionthe residue is extracted three times with ethyl acetate
  3. washThe combined organic phases are washed with water
  4. dry with materialdried over sodium sulphate
  5. customevaporated
  6. custom0.97 g of product is recovered (yield=100%)

出典と根拠

ORDレコード
ord-a557920ddb094b44a10596349cbb5474
出典データセット
uspto-grants-2003_02
特許番号
US06518260B1

反応ノート

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