Sodium Iodide → 3-(3-Methoxy-4-phenylmethoxyphenyl)prop-2-enal

HRID 1059032

反応式

HRID 1059032 の反応式
[OH:1][C:2]1[CH:11]=[CH:10][C:5]([CH:6]=[CH:7][CH:8]=[O:9])=[CH:4][C:3]=1[O:12][CH3:13].[CH2:14](Cl)[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1.C([O-])([O-])=O.[K+].[K+].[Na+].[I-]>CC(C)=O>[CH2:14]([O:1][C:2]1[CH:11]=[CH:10][C:5]([CH:6]=[CH:7][CH:8]=[O:9])=[CH:4][C:3]=1[O:12][CH3:13])[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1

参加物

6

反応物 4

HCID 5238Sodium IodideHCID 7503Benzyl ChlorideHCID 99842-Propenal, 3-(4-hydroxy-3-methoxyphenyl)-HCID 11430Potassium Carbonate

生成物 1

HCID 537901463-(3-Methoxy-4-phenylmethoxyphenyl)prop-2-enal収率 85%

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

4-Hydroxy-3-methoxycinnamaldehyde (0.6 g) was added to the mixture of benzyl chloride (1 mL), K2CO3 (1 g), and NaI (1 g) in acetone (20 mL). The resulting mixture was stirred at room temperature for 24 hrs. The solid were removed by filtration and washed with acetone. After evaporation of solvent, the crude product was purified by gradient chromatography to give a yellowish solid. Yield 85%.

後処理

  1. customThe solid were removed by filtration
  2. washwashed with acetone
  3. customAfter evaporation of solvent
  4. customthe crude product was purified by gradient chromatography
  5. customto give a yellowish solid

出典と根拠

ORDレコード
ord-fbb54ea6072e472ebc9d8fcc69187f33
出典データセット
uspto-grants-2003_02
特許番号
US06518315B1

関連ノート

読み込み中…