Sodium Carbonate → 1-(4'-chloro[1,1'-biphenyl]-4-yl)-1-(1-trityl-1H-imidazol-4-yl)-2-methyl-1-propanol

HRID 1059137ノート

反応式

HRID 1059137 の反応式
Br[C:2]1[CH:7]=[CH:6][C:5]([C:8]([C:13]2[N:14]=[CH:15][N:16]([C:18]([C:31]3[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=3)([C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=3)[C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)[CH:17]=2)([OH:12])[CH:9]([CH3:11])[CH3:10])=[CH:4][CH:3]=1.[Cl:37][C:38]1[CH:43]=[CH:42][C:41](B(O)O)=[CH:40][CH:39]=1.C(=O)([O-])[O-].[Na+].[Na+]>C1C=CC([P]([Pd]([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1>[Cl:37][C:38]1[CH:43]=[CH:42][C:41]([C:2]2[CH:7]=[CH:6][C:5]([C:8]([C:13]3[N:14]=[CH:15][N:16]([C:18]([C:25]4[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=4)([C:19]4[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=4)[C:31]4[CH:32]=[CH:33][CH:34]=[CH:35][CH:36]=4)[CH:17]=3)([OH:12])[CH:9]([CH3:10])[CH3:11])=[CH:4][CH:3]=2)=[CH:40][CH:39]=1

参加物

5

反応物 3

HCID 10340Sodium CarbonateHCID 742994-Chlorophenylboronic acidHCID 120433871-(4-bromophenyl)-(1-trityl-1H-imidazol-4-yl)-2-methyl-1-propanol

生成物 1

HCID 120433891-(4'-chloro[1,1'-biphenyl]-4-yl)-1-(1-trityl-1H-imidazol-4-yl)-2-methyl-1-propanol収率 79.7%

試薬・触媒・溶媒 1

HCID 178418397HCID 178418397、化合物触媒

実験手順

By the reaction in the same manner as in Example 4-(ii) using 1-(4-bromophenyl)-(1-trityl-1H-imidazol-4-yl)-2-methyl-1-propanol (3.60 g), 4-chlorophenylboronic acid (1.68 g), 2M aqueous sodium carbonate solution (26.8 ml) and tetrakis(triphenylphosphine)palladium(0) (387 mg), the title compound (3.04 g) was obtained as colorless needle crystals.

後処理

  1. customBy the reaction in the same manner as in Example

出典と根拠

ORDレコード
ord-8929565e730248249de825650200082a
出典データセット
uspto-grants-2003_02
特許番号
US06518257B1

反応ノート

読み込み中…