Sodium Carbonate → 4'-Fluoro-2-methoxy-1,1'-biphenyl

HRID 1059253ノート

反応式

HRID 1059253 の反応式
Br[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[O:8][CH3:9].[F:10][C:11]1[CH:16]=[CH:15][C:14](B(O)O)=[CH:13][CH:12]=1.C(=O)([O-])[O-].[Na+].[Na+]>C1C=CC([P]([Pd]([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1>[CH3:9][O:8][C:3]1[C:2]([C:14]2[CH:15]=[CH:16][C:11]([F:10])=[CH:12][CH:13]=2)=[CH:7][CH:6]=[CH:5][CH:4]=1

参加物

5

反応物 3

HCID 10340Sodium CarbonateHCID 113582-BromoanisoleHCID 2856454-Fluorophenylboronic acid

生成物 1

HCID 130895414'-Fluoro-2-methoxy-1,1'-biphenyl収率 84.5%

試薬・触媒・溶媒 1

HCID 178418397HCID 178418397、化合物触媒

実験手順

By the reaction in the same manner as in Example 4-(ii) using 2-bromoanisole (8.91 g), 4-fluorophenylboronic acid (10.0 g), 2M aqueous sodium carbonate solution (47.6 ml) and tetrakis(triphenylphosphine)palladium(0) (2.20 g), the title compound (8.14 g) was obtained as colorless needle crystals.

後処理

  1. customBy the reaction in the same manner as in Example

出典と根拠

ORDレコード
ord-a689a4a845844721b3654600a706b84d
出典データセット
uspto-grants-2003_02
特許番号
US06518257B1

反応ノート

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